What the FDA labels say about taking them together
Lisdexamfetamine and tramadol
Lisdexamfetamine's FDA label of April 30, 2026 names tramadol in its warnings and precautions section; the tramadol labels PlainMeds reads (3) do not name lisdexamfetamine. The lisdexamfetamine label: “… inhibitors (SNRIs), triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St. John's Wort.”
Check it at the source: the lisdexamfetamine FDA label on DailyMed (effective April 30, 2026, Takeda Pharmaceuticals America, Inc.); the tramadol FDA label on DailyMed (effective March 5, 2026, Lupin Pharmaceuticals, Inc.).
What does the lisdexamfetamine label say about tramadol?
Lisdexamfetamine label, warnings and precautionsSerotonin syndrome, a potentially life-threatening reaction, may occur when amphetamines are used in combination with other drugs that affect the serotonergic neurotransmitter systems such as monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St. John's Wort [see Drug Interactions (7.1) ].
Source: FDA drug label (Vyvanse), Takeda Pharmaceuticals America, Inc., effective April 30, 2026 (SPL set 704e4378-ca83-445c-8b45-3cfa51c1ecad), via openFDA; the full label on DailyMed
What does the tramadol label say about lisdexamfetamine?
Tramadol's label (effective March 5, 2026) and its 2 other brand-application labels do not name lisdexamfetamine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (TRAMADOL HYDROCHLORIDE), Lupin Pharmaceuticals, Inc., effective March 5, 2026 (SPL set 46bb9ae6-3ee8-463c-badb-c7a45a89b84b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lisdexamfetamine | Tramadol | |
|---|---|---|
| Labeled for | ADHD, Binge eating disorder | Pain |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $2.44 per capsule 20 mg capsule | $0.0248 per tablet 50 mg tablet |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once