What the FDA labels say about taking them together
Lisdexamfetamine and methylene blue
Lisdexamfetamine's FDA label of April 30, 2026 names methylene blue in its contraindications section; the methylene blue label PlainMeds reads does not name lisdexamfetamine. The lisdexamfetamine label: “Patients taking monoamine oxidase inhibitors (MAOIs), or within 14 days of stopping MAOIs, because of an increased risk of hypertensive crisis.”
Check it at the source: the lisdexamfetamine FDA label on DailyMed (effective April 30, 2026, Takeda Pharmaceuticals America, Inc.); the methylene blue FDA label on DailyMed (effective May 28, 2025, American Regent, Inc.).
What does the lisdexamfetamine label say about methylene blue?
Lisdexamfetamine label, contraindicationsPatients taking monoamine oxidase inhibitors (MAOIs), or within 14 days of stopping MAOIs (including MAOIs such as linezolid or intravenous methylene blue), because of an increased risk of hypertensive crisis [see Warnings and Precautions (5.7) and Drug Interactions (7.1) ].
Source: FDA drug label (Vyvanse), Takeda Pharmaceuticals America, Inc., effective April 30, 2026 (SPL set 704e4378-ca83-445c-8b45-3cfa51c1ecad), via openFDA; the full label on DailyMed
What does the methylene blue label say about lisdexamfetamine?
Methylene blue's label (effective May 28, 2025) does not name lisdexamfetamine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (PROVAYBLUE), NDA204630 (Provepharm Sas), as published by American Regent, Inc., effective May 28, 2025 (SPL set 4f6848e5-35ed-4046-b13c-3032b5ba3232), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lisdexamfetamine | Methylene blue | |
|---|---|---|
| Labeled for | ADHD, Binge eating disorder | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $2.44 per capsule 20 mg capsule | n/a |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once