What the FDA labels say about taking them together
Dexamethasone and liothyronine
Liothyronine's FDA label of June 4, 2026 names dexamethasone in its drug interactions section; the dexamethasone labels PlainMeds reads (4) do not name liothyronine. The liothyronine label: “Glucocorticoids Short-term administration of large doses of glucocorticoids may decrease serum T3 concentrations by 30% with minimal change in serum T4 levels.”
Check it at the source: the dexamethasone FDA label on DailyMed (effective June 6, 2025, Hikma Pharmaceuticals USA, Inc.); the liothyronine FDA label on DailyMed (effective June 4, 2026, Mylan Pharmaceuticals Inc.).
What does the dexamethasone label say about liothyronine?
Dexamethasone's label (effective June 6, 2025) and its 3 other brand-application labels do not name liothyronine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Dexamethasone Intensol), Hikma Pharmaceuticals USA, Inc., effective June 6, 2025 (SPL set b15200fb-1826-472b-a907-e677a272513b), via openFDA; the full label on DailyMed
What does the liothyronine label say about dexamethasone?
Liothyronine label, drug interactionsGlucocorticoids (e.g., Dexamethasone ≥4 mg/day) Short-term administration of large doses of glucocorticoids may decrease serum T3 concentrations by 30% with minimal change in serum T4 levels.
Source: FDA drug label (Liothyronine Sodium), NDA010379 (King Pharms), as published by Mylan Pharmaceuticals Inc., effective June 4, 2026 (SPL set 115a84c2-0126-4dd7-816e-1873875f1e49), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dexamethasone | Liothyronine | |
|---|---|---|
| Labeled for | Asthma, Eczema (atopic dermatitis), Leukemia, lymphoma and myeloma, Herpes and shingles, Crohn's disease and ulcerative colitis, Multiple sclerosis, Osteoarthritis, Rheumatoid arthritis, Psoriasis, Allergies, Anemia, Pain | Hypothyroidism |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.193 per tablet 4 mg tablet | $0.294 per tablet 25 mcg tablet |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once