What the FDA labels say about taking them together
Lidocaine/prilocaine and sotalol
Lidocaine/prilocaine's FDA label of March 30, 2026 names sotalol in its drug interactions section; the sotalol labels PlainMeds reads (3) do not name lidocaine/prilocaine. The lidocaine/prilocaine label: “Patients treated with class III anti-arrhythmic drugs should be under close surveillance and ECG monitoring considered, because cardiac effects may be additive.”
Check it at the source: the lidocaine/prilocaine FDA label on DailyMed (effective March 30, 2026, Padagis US LLC); the sotalol FDA label on DailyMed (effective December 16, 2024, Legacy Pharma USA, Inc.).
What does the lidocaine/prilocaine label say about sotalol?
Lidocaine/prilocaine label, drug interactions… Anticonvulsants phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine Specific interaction studies with lidocaine/prilocaine and class III anti-arrhythmic drugs (e.g., amiodarone, bretylium, sotalol, dofetilide) have not been performed, but caution is advised (see WARNINGS).
Lidocaine/prilocaine label, warningsPatients treated with class III anti-arrhythmic drugs (e.g., amiodarone, bretylium, sotalol, dofetilide) should be under close surveillance and ECG monitoring considered, because cardiac effects may be additive.
Source: FDA drug label (LIDOCAINE AND PRILOCAINE), Padagis US LLC, effective March 30, 2026 (SPL set 6e1635f7-dcae-441b-bbf7-495661fb66ae), via openFDA; the full label on DailyMed
What does the sotalol label say about lidocaine/prilocaine?
Sotalol's label (effective December 16, 2024) and its 2 other brand-application labels do not name lidocaine/prilocaine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (BETAPACE), Legacy Pharma USA, Inc., effective December 16, 2024 (SPL set a6a7702f-36c9-45db-b640-453dc324baee), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lidocaine/prilocaine | Sotalol | |
|---|---|---|
| Labeled for | n/a | Atrial fibrillation |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.232 per gram 2.5%-2.5% cream | $0.0707 per tablet 80 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once