What the FDA labels say about taking them together
Lidocaine/prilocaine and mexiletine
Lidocaine/prilocaine's FDA label of March 30, 2026 names mexiletine in its drug interactions section; the mexiletine label PlainMeds reads does not name lidocaine/prilocaine.
Check it at the source: the lidocaine/prilocaine FDA label on DailyMed (effective March 30, 2026, Padagis US LLC); the mexiletine FDA label on DailyMed (effective May 14, 2026, Macleods Pharmaceuticals Limited).
What does the lidocaine/prilocaine label say about mexiletine?
Lidocaine/prilocaine label, drug interactionsDrug Interactions: Lidocaine and Prilocaine Cream should be used with caution in patients receiving Class I antiarrhythmic drugs (such as tocainide and mexiletine) since the toxic effects are additive and potentially synergistic.
Oraqix label (Dentsply Pharmaceutical, April 21, 2026), drug interactionsAnesthetics or Agents Structurally Related to Local Anesthetics Oraqix should be used with caution in combination with dental injection anesthesia, other local anesthetics, or agents structurally related to local anesthetics, e.g., Class 1 antiarrhythmics such as tocainide and mexiletine, as the toxic effects of these drugs are likely to be additive and potentially synergistic.
Source: FDA drug label (Oraqix, NDA021451), Dentsply Pharmaceutical, effective April 21, 2026 (SPL set b501d239-923b-48b2-82ed-6c5c253a67e2), via openFDA
Source: FDA drug label (LIDOCAINE AND PRILOCAINE), Padagis US LLC, effective March 30, 2026 (SPL set 6e1635f7-dcae-441b-bbf7-495661fb66ae), via openFDA; the full label on DailyMed
What does the mexiletine label say about lidocaine/prilocaine?
Mexiletine's label (effective May 14, 2026) does not name lidocaine/prilocaine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Mexiletine Hydrochloride), Macleods Pharmaceuticals Limited, effective May 14, 2026 (SPL set a61a07f6-0b48-4dcd-ad42-5d90f6e69ab1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lidocaine/prilocaine | Mexiletine | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.232 per gram 2.5%-2.5% cream | $0.222 per capsule 150 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once