What the FDA labels say about taking them together
Lidocaine and sodium bicarbonate
Sodium bicarbonate's FDA label of August 4, 2026 names lidocaine in its warnings and precautions (prescription label) section; the lidocaine labels PlainMeds reads (4) do not name sodium bicarbonate. The sodium bicarbonate label: “Prompt elevation of the area, warmth, and local injection of lidocaine or hyaluronidase are recommended to reduce the likelihood of tissue sloughing at the site.”
Check it at the source: the lidocaine FDA label on DailyMed (effective May 13, 2024, Fresenius Kabi USA, LLC); the sodium bicarbonate FDA label on DailyMed (effective August 4, 2026).
What does the lidocaine label say about sodium bicarbonate?
Lidocaine's label (effective May 13, 2024) and its 3 other brand-application labels do not name sodium bicarbonate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Xylocaine MPF), Fresenius Kabi USA, LLC, effective May 13, 2024 (SPL set d5e0d06f-ba1e-44d4-aa89-39d6c146dc23), via openFDA; the full label on DailyMed
What does the sodium bicarbonate label say about lidocaine?
Sodium bicarbonate label, warnings and precautions (prescription label)Extravasation: Prompt elevation of the area, warmth, and local injection of lidocaine or hyaluronidase are recommended to reduce the likelihood of tissue sloughing at the site.
Source: FDA drug label (Sodium Bicarbonate, NDA220790), Amneal Pharmaceuticals Private Limited, effective July 9, 2026 (SPL set ac91e834-e693-43a2-829b-56793453e8cc), via openFDA
Source: FDA drug label (Sodium Bicarbonate 5 gr), TWIN MED LLC, effective August 4, 2026 (SPL set e325d899-d9a6-5adb-e053-2995a90ac861), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lidocaine | Sodium bicarbonate | |
|---|---|---|
| Labeled for | Pain | Acid reflux and ulcers, Diarrhea |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.154 per gram 5% ointment | $0.154 per mL 8.4% vial |
| Shortage now | In shortage | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once