What the FDA labels say about taking them together
Lidocaine and raloxifene
Raloxifene's FDA label of April 14, 2026 names lidocaine in its drug interactions section; the lidocaine labels PlainMeds reads (4) do not name raloxifene.
Check it at the source: the lidocaine FDA label on DailyMed (effective May 13, 2024, Fresenius Kabi USA, LLC); the raloxifene FDA label on DailyMed (effective April 14, 2026, Amneal Pharmaceuticals LLC).
What does the lidocaine label say about raloxifene?
Lidocaine's label (effective May 13, 2024) and its 3 other brand-application labels do not name raloxifene in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Xylocaine MPF), Fresenius Kabi USA, LLC, effective May 13, 2024 (SPL set d5e0d06f-ba1e-44d4-aa89-39d6c146dc23), via openFDA; the full label on DailyMed
What does the raloxifene label say about lidocaine?
Raloxifene label, drug interactionsRaloxifene hydrochloride should be used with caution with certain other highly protein-bound drugs such as diazepam, diazoxide, and lidocaine.
Source: FDA drug label (Evista, NDA020815), Eli Lilly and Company, effective February 11, 2026 (SPL set fcaaa6dc-74e8-4fb8-800c-5574bf0f8de9), via openFDA
Source: FDA drug label (Raloxifene Hydrochloride), Amneal Pharmaceuticals LLC, effective April 14, 2026 (SPL set 3798c70b-a4b0-4811-9788-e4c9cff47ebe), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lidocaine | Raloxifene | |
|---|---|---|
| Labeled for | Pain | Osteoporosis, Breast cancer |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.154 per gram 5% ointment | $0.223 per tablet 60 mg tablet |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once