What the FDA labels say about taking them together
Lidocaine and propofol
Lidocaine's FDA label (Lidocaine Hydrochloride And Dextrose) of February 20, 2026 names propofol in its drug interactions section, and propofol's label names lidocaine too. The propofol label: “Pain during intravenous injection may also be reduced by prior injection of intravenous lidocaine (1 mL of a 1% solution).”
Check it at the source: the lidocaine FDA label on DailyMed (effective May 13, 2024, Fresenius Kabi USA, LLC); the propofol FDA label on DailyMed (effective September 11, 2025, Fresenius Kabi USA, LLC).
What does the lidocaine label say about propofol?
Lidocaine Hydrochloride And Dextrose label (Baxter Healthcare Corporation, February 20, 2026), drug interactionsConcomitant use of lidocaine with propofol, a hypnotic agent and CYP3A4 inhibitor, may increase lidocaine plasma levels by reducing lidocaine clearance.
Source: FDA drug label (Lidocaine Hydrochloride And Dextrose, NDA018461), Baxter Healthcare Corporation, effective February 20, 2026 (SPL set f21512ea-c7c3-4766-b976-b2c0b5616bf0), via openFDA
Source: FDA drug label (Xylocaine MPF), Fresenius Kabi USA, LLC, effective May 13, 2024 (SPL set d5e0d06f-ba1e-44d4-aa89-39d6c146dc23), via openFDA; the full label on DailyMed
What does the propofol label say about lidocaine?
Propofol label, warnings and precautionsPain during intravenous injection may also be reduced by prior injection of intravenous lidocaine (1 mL of a 1% solution).
Source: FDA drug label (Diprivan), Fresenius Kabi USA, LLC, effective September 11, 2025 (SPL set e3105799-a4b6-f3f4-e6e2-b2b29bbdb538), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lidocaine | Propofol | |
|---|---|---|
| Labeled for | Pain | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.154 per gram 5% ointment | $0.171 per mL 200 mg/20 mL vial |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once