What the FDA labels say about taking them together
Lidocaine and propafenone
Propafenone's FDA label of September 1, 2025 names lidocaine in its drug interactions section; the lidocaine labels PlainMeds reads (4) do not name propafenone. The propafenone label: “Taper orlistat withdrawal. Lidocaine may increase central nervous system side effects.”
Check it at the source: the lidocaine FDA label on DailyMed (effective May 13, 2024, Fresenius Kabi USA, LLC); the propafenone FDA label on DailyMed (effective September 1, 2025, Strides Pharma Science Limited).
What does the lidocaine label say about propafenone?
Lidocaine's label (effective May 13, 2024) and its 3 other brand-application labels do not name propafenone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Xylocaine MPF), Fresenius Kabi USA, LLC, effective May 13, 2024 (SPL set d5e0d06f-ba1e-44d4-aa89-39d6c146dc23), via openFDA; the full label on DailyMed
What does the propafenone label say about lidocaine?
Propafenone label, drug interactionsTaper orlistat withdrawal. (7.4) Lidocaine may increase central nervous system side effects.
Source: FDA drug label (PROPAFENONE HYDROCHLORIDE), Strides Pharma Science Limited, effective September 1, 2025 (SPL set c65253ab-937f-4982-b841-69c2b9f9ccdb), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lidocaine | Propafenone | |
|---|---|---|
| Labeled for | Pain | Atrial fibrillation |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.154 per gram 5% ointment | $0.115 per tablet 150 mg tablet |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once