What the FDA labels say about taking them together
Lidocaine and phentolamine
Phentolamine's FDA label (Oraverse) of December 5, 2018 names lidocaine in its drug interactions section; the lidocaine labels PlainMeds reads (4) do not name phentolamine. The phentolamine label: “Lidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration …”
Check it at the source: the lidocaine FDA label on DailyMed (effective May 13, 2024, Fresenius Kabi USA, LLC); the phentolamine FDA label on DailyMed (effective March 15, 2026, Oyster Point Pharma, Inc.).
What does the lidocaine label say about phentolamine?
Lidocaine's label (effective May 13, 2024) and its 3 other brand-application labels do not name phentolamine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Xylocaine MPF), Fresenius Kabi USA, LLC, effective May 13, 2024 (SPL set d5e0d06f-ba1e-44d4-aa89-39d6c146dc23), via openFDA; the full label on DailyMed
What does the phentolamine label say about lidocaine?
Oraverse label (Septodont, Inc., December 5, 2018), drug interactionsLidocaine and Epinephrine When OraVerse was administered as an intraoral submucosal injection 30 minutes after injection of a local anesthetic, 2% lidocaine HCl with 1:100,000 epinephrine, the lidocaine concentration increased immediately after OraVerse intraoral injection.
Source: FDA drug label (Oraverse, NDA022159), Septodont, Inc., effective December 5, 2018 (SPL set 4025cf98-ea87-4531-b0fc-6283c84f63f3), via openFDA
Source: FDA drug label (Ryzumvi), NDA217064 (Famygen Life Sci), as published by Oyster Point Pharma, Inc., effective March 15, 2026 (SPL set 96bb1e53-c2cc-4e60-a21a-db0269c371bf), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lidocaine | Phentolamine | |
|---|---|---|
| Labeled for | Pain | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.154 per gram 5% ointment | n/a |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once