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What the FDA labels say about taking them together

Lidocaine and nevirapine

Nevirapine's FDA label of July 15, 2026 names lidocaine in its drug interactions section; the lidocaine labels PlainMeds reads (4) do not name nevirapine. The nevirapine label: “Antiarrhythmics: Amiodarone, disopyramide, lidocaine Plasma concentrations may be decreased.”

Check it at the source: the lidocaine FDA label on DailyMed (effective May 13, 2024, Fresenius Kabi USA, LLC); the nevirapine FDA label on DailyMed (effective July 15, 2026, Mylan Pharmaceuticals Inc.).

What does the lidocaine label say about nevirapine?

Lidocaine's label (effective May 13, 2024) and its 3 other brand-application labels do not name nevirapine in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Xylocaine MPF), Fresenius Kabi USA, LLC, effective May 13, 2024 (SPL set d5e0d06f-ba1e-44d4-aa89-39d6c146dc23), via openFDA; the full label on DailyMed

What does the nevirapine label say about lidocaine?

Nevirapine label, drug interactions

Antiarrhythmics: Amiodarone, disopyramide, lidocaine Plasma concentrations may be decreased.

Source: FDA drug label (Nevirapine), Mylan Pharmaceuticals Inc., effective July 15, 2026 (SPL set c6e93829-7024-48f6-8023-da6ff27dfc0a), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

81Lidocaine generic labelers
6Nevirapine generic labelers
LidocaineNevirapine
Labeled forPainHIV
Boxed warningNoYes
Pharmacy cost (NADAC)$0.154 per gram 5% ointment$0.147 per tablet 200 mg tablet
Shortage nowIn shortageNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

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