What the FDA labels say about taking them together
Levonorgestrel and teriflunomide
Teriflunomide's FDA label of February 20, 2026 names levonorgestrel in its drug interactions section; the levonorgestrel labels PlainMeds reads (4) do not name teriflunomide. The teriflunomide label: “… these drugs. Teriflunomide may increase exposure of ethinylestradiol and levonorgestrel.”
Check it at the source: the levonorgestrel FDA label on DailyMed (effective January 31, 2023, Foundation Consumer Healthcare LLC); the teriflunomide FDA label on DailyMed (effective February 20, 2026, Genzyme Corporation).
What does the levonorgestrel label say about teriflunomide?
Levonorgestrel's label (effective January 31, 2023) and its 3 other brand-application labels do not name teriflunomide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Plan B One-Step), Foundation Consumer Healthcare LLC, effective January 31, 2023 (SPL set 6ce6b40e-14ac-47bd-a648-ddf9e452e559), via openFDA; the full label on DailyMed
What does the teriflunomide label say about levonorgestrel?
Teriflunomide label, drug interactionsDRUG INTERACTIONS Drugs metabolized by CYP2C8 and OAT3 transporters: Monitor patients because teriflunomide may increase exposure of these drugs. ( 7 ) Teriflunomide may increase exposure of ethinylestradiol and levonorgestrel.
Source: FDA drug label (Aubagio), NDA202992 (Sanofi Aventis Us), as published by Genzyme Corporation, effective February 20, 2026 (SPL set 4650d12c-b9c8-4525-b07f-a2d773eca155), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Levonorgestrel | Teriflunomide | |
|---|---|---|
| Labeled for | Birth control | Multiple sclerosis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $6.33 per tablet 1.5 mg tablet | $0.233 per tablet 14 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once