What the FDA labels say about taking them together
Levonorgestrel and suzetrigine
Suzetrigine's FDA label of April 13, 2026 names levonorgestrel in its drug interactions section; the levonorgestrel labels PlainMeds reads (4) do not name suzetrigine.
Check it at the source: the levonorgestrel FDA label on DailyMed (effective January 31, 2023, Foundation Consumer Healthcare LLC); the suzetrigine FDA label on DailyMed (effective April 13, 2026, Vertex Pharmaceuticals Incorporated).
What does the levonorgestrel label say about suzetrigine?
Levonorgestrel's label (effective January 31, 2023) and its 3 other brand-application labels do not name suzetrigine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Plan B One-Step), Foundation Consumer Healthcare LLC, effective January 31, 2023 (SPL set 6ce6b40e-14ac-47bd-a648-ddf9e452e559), via openFDA; the full label on DailyMed
What does the suzetrigine label say about levonorgestrel?
Suzetrigine label, drug interactionsJOURNAVX-treated patients using hormonal contraceptives containing progestins other than levonorgestrel and norethindrone should use an additional nonhormonal contraceptive method or an alternative hormonal contraceptive during concomitant use and for 28 days after JOURNAVX discontinuation.
Suzetrigine label, warnings and precautionsInteractions with Certain Hormonal Contraceptives JOURNAVX-treated patients taking concomitant hormonal contraceptives containing progestins other than levonorgestrel and norethindrone should use additional nonhormonal contraceptives (such as condoms) or use alternative contraceptives (e.g., a combined oral contraceptive containing ethinyl estradiol as the estrogen and levonorgestrel or norethindrone as the progestin, an intrauterine system) during JOURNAVX treatment and for 28 days after discontinuation of JOURNAVX [see Drug Interactions (7.2), Clinical Pharmacology (12.3) ].
Source: FDA drug label (JOURNAVX), Vertex Pharmaceuticals Incorporated, effective April 13, 2026 (SPL set f0976da4-1d20-4517-945c-b60ed2f41c12), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Levonorgestrel | Suzetrigine | |
|---|---|---|
| Labeled for | Birth control | Pain |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $6.33 per tablet 1.5 mg tablet | $15.41 per tablet 50 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once