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What the FDA labels say about taking them together

Levonorgestrel and pacritinib

Pacritinib's FDA label of July 30, 2026 names levonorgestrel in its drug interactions section; the levonorgestrel labels PlainMeds reads (4) do not name pacritinib. The pacritinib label: “Hormonal Contraceptives Avoid concomitant use of VONJO with hormonal contraceptives except for intrauterine systems containing levonorgestrel.”

Check it at the source: the levonorgestrel FDA label on DailyMed (effective January 31, 2023, Foundation Consumer Healthcare LLC); the pacritinib FDA label on DailyMed (effective July 30, 2026, Sobi, Inc.).

What does the levonorgestrel label say about pacritinib?

Levonorgestrel's label (effective January 31, 2023) and its 3 other brand-application labels do not name pacritinib in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Plan B One-Step), Foundation Consumer Healthcare LLC, effective January 31, 2023 (SPL set 6ce6b40e-14ac-47bd-a648-ddf9e452e559), via openFDA; the full label on DailyMed

What does the pacritinib label say about levonorgestrel?

Pacritinib label, drug interactions

Hormonal Contraceptives Avoid concomitant use of VONJO with hormonal contraceptives except for intrauterine systems containing levonorgestrel.

Source: FDA drug label (Vonjo), Sobi, Inc., effective July 30, 2026 (SPL set 4b5ab444-0e1a-4984-99db-76ad11a298ee), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

31Levonorgestrel generic labelers
0Pacritinib generic labelers
LevonorgestrelPacritinib
Labeled forBirth controln/a
Boxed warningNoNo
Pharmacy cost (NADAC)$6.33 per tablet 1.5 mg tabletn/a
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?