Levomilnacipran and Lithium Interaction
Drug interaction information between Levomilnacipran and Lithium.
Levomilnacipran and Lithium have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Levomilnacipran and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines increase a chemical called serotonin in your brain, and taking them together can cause serotonin levels to become too high.
FDA Label Information
Examples: other SNRIs, SSRIs, triptans, tricyclic antidepressants, opioids, lithium, buspirone, amphetamines, tryptophan, and St.
Levomilnacipran Also Interacts With
- Linezolid moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
- Buspirone minor
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Levomilnacipran + Lithium?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Levomilnacipran's 11. In the minor band specifically: Levomilnacipran has 7 (also Buspirone, Aspirin, Warfarin, Ketoconazole); Lithium has 65 (also Aripiprazole, Asenapine, Canagliflozin, Candesartan).
What mechanism field is on file for Levomilnacipran and Lithium?
Both of these medicines increase a chemical called serotonin in your brain, and taking them together can cause serotonin levels to become too high.
Lithium carries more major-labeled pairs than Levomilnacipran
SPL source-record counts only. This page's band is minor · classes on file: Levomilnacipran (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)); Lithium (Mood Stabilizer).
Lithium has 2 major-labeled pairs vs Levomilnacipran's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 7 minor · 11 total
- Other minor peers for Levomilnacipran
- Buspirone
- Aspirin
- Warfarin
- Ketoconazole
2 major · 23 moderate · 65 minor · 90 total
- Other minor peers for Lithium
- Aripiprazole
- Asenapine
- Canagliflozin
- Candesartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.