Levomilnacipran and Ketoconazole Interaction
Drug interaction information between Levomilnacipran and Ketoconazole.
Levomilnacipran and Ketoconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Levomilnacipran and Ketoconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ketoconazole can slow down how your body breaks down levomilnacipran, which may cause the drug to build up in your system.
FDA Label Information
Examples: Ketoconazole, itraconazole, clarithromycin Alcohol Clinical Impact: Concomitant use of FETZIMA and alcohol may result in accelerated release of levomilnacipran.
Levomilnacipran Also Interacts With
- Linezolid moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
- Buspirone minor
Ketoconazole Also Interacts With
- Alfuzosin major
- Dronedarone major
- Ranolazine major
- Saxagliptin major
- Sildenafil major
Frequently Asked Questions
What SPL severity band is on file for Levomilnacipran + Ketoconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ketoconazole has 113 labeled pairs on file vs Levomilnacipran's 11. In the minor band specifically: Levomilnacipran has 7 (also Buspirone, Aspirin, Warfarin, Lithium); Ketoconazole has 85 (also Abiraterone, Acetaminophen/Oxycodone, Alosetron, Amphotericin B).
What mechanism field is on file for Levomilnacipran and Ketoconazole?
Ketoconazole can slow down how your body breaks down levomilnacipran, which may cause the drug to build up in your system.
Ketoconazole carries more major-labeled pairs than Levomilnacipran
SPL source-record counts only. This page's band is minor · classes on file: Levomilnacipran (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)); Ketoconazole (Azole Antifungal).
Ketoconazole has 6 major-labeled pairs vs Levomilnacipran's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 7 minor · 11 total
6 major · 22 moderate · 85 minor · 113 total
- Other minor peers for Ketoconazole
- Abiraterone
- Acetaminophen/Oxycodone
- Alosetron
- Amphotericin B
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.