What the FDA labels say about taking them together
Itraconazole and levomilnacipran
Levomilnacipran's FDA label of April 30, 2024 names itraconazole in its drug interactions section; the itraconazole labels PlainMeds reads (2) do not name levomilnacipran. The levomilnacipran label: “Concomitant use of FETZIMA with strong CYP3A4 inhibitors increases levomilnacipran exposure.”
Check it at the source: the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.); the levomilnacipran FDA label on DailyMed (effective April 30, 2024, Allergan, Inc.).
What does the itraconazole label say about levomilnacipran?
Itraconazole's label (effective July 13, 2026) and its 1 other brand-application label do not name levomilnacipran in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
What does the levomilnacipran label say about itraconazole?
Levomilnacipran label, drug interactionsStrong CYP3A4 Inhibitors Clinical Impact: Concomitant use of FETZIMA with strong CYP3A4 inhibitors increases levomilnacipran exposure. Intervention: The dose of FETZIMA should not exceed 80 mg once daily when used with strong CYP3A4 inhibitors [see Dosage and Administration (). Examples: Ketoconazole, itraconazole, clarithromycin
Source: FDA drug label (Fetzima), NDA204168 (Abbvie), as published by Allergan, Inc., effective April 30, 2024 (SPL set f371258d-91b3-4b6a-ac99-434a1964c3af), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Itraconazole | Levomilnacipran | |
|---|---|---|
| Labeled for | Fungal infections | Depression |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.910 per capsule 100 mg capsule | $17.61 per unit 20-40 mg titration pak |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once