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What the FDA labels say about taking them together

Levoketoconazole and sucralfate

Levoketoconazole's FDA label of March 10, 2026 names sucralfate in its drug interactions section; the sucralfate labels PlainMeds reads (2) do not name levoketoconazole. The levoketoconazole label: “Prevention or Management; Avoid use of sucralfate with RECORLEV.”

Check it at the source: the levoketoconazole FDA label on DailyMed (effective March 10, 2026, Xeris Pharmaceuticals, Inc.); the sucralfate FDA label on DailyMed (effective September 2, 2026, Preferred Pharmaceuticals Inc.).

What does the levoketoconazole label say about sucralfate?

Levoketoconazole label, drug interactions

Prevention or Management; Avoid use of sucralfate with RECORLEV.

Source: FDA drug label (Recorlev), NDA214133 (Strongbridge), as published by Xeris Pharmaceuticals, Inc., effective March 10, 2026 (SPL set d4c5fead-bc4a-fb02-e053-2a95a90ae4fc), via openFDA; the full label on DailyMed

What does the sucralfate label say about levoketoconazole?

Sucralfate's label (effective September 2, 2026) and its 1 other brand-application label do not name levoketoconazole in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Sucralfate), NDA018333 (Abbvie), as published by Preferred Pharmaceuticals Inc., effective September 2, 2026 (SPL set 536b8c00-13ab-4397-a754-63a1c92bf883), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

0Levoketoconazole generic labelers
43Sucralfate generic labelers
LevoketoconazoleSucralfate
Labeled forn/aAcid reflux and ulcers
Boxed warningYesNo
Pharmacy cost (NADAC)n/a$0.173 per tablet 1 g tablet
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?