What the FDA labels say about taking them together
Levoketoconazole and metformin
Levoketoconazole's FDA label of March 10, 2026 names metformin in its drug interactions section; the metformin labels PlainMeds reads (3) do not name levoketoconazole. The levoketoconazole label: “Use lowest atorvastatin dose possible and monitor for adverse reactions for dosages exceeding 20 mg daily Metformin:”
Check it at the source: the levoketoconazole FDA label on DailyMed (effective March 10, 2026, Xeris Pharmaceuticals, Inc.); the metformin FDA label on DailyMed (effective September 3, 2026, Granules India Ltd).
What does the levoketoconazole label say about metformin?
Levoketoconazole label, drug interactionsUse lowest atorvastatin dose possible and monitor for adverse reactions for dosages exceeding 20 mg daily ( 7.1 ) Metformin:
Source: FDA drug label (Recorlev), NDA214133 (Strongbridge), as published by Xeris Pharmaceuticals, Inc., effective March 10, 2026 (SPL set d4c5fead-bc4a-fb02-e053-2a95a90ae4fc), via openFDA; the full label on DailyMed
What does the metformin label say about levoketoconazole?
Metformin's label (effective September 3, 2026) and its 2 other brand-application labels do not name levoketoconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (METFORMIN HYDROCHLORIDE), Granules India Ltd, effective September 3, 2026 (SPL set 73197cb5-3e23-4ac0-b189-f9bc848bce66), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Levoketoconazole | Metformin | |
|---|---|---|
| Labeled for | n/a | Type 2 diabetes |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $0.0145 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once