What the FDA labels say about taking them together
Levodopa and tolcapone
Tolcapone's FDA label of October 2, 2020 names levodopa in its drug interactions section; the levodopa label PlainMeds reads does not name tolcapone. The tolcapone label: “Falling Asleep During Activities of Daily Living and Somnolence Tolcapone (TASMAR) increases plasma levels of levodopa in patients taking concomitant carbidopa levodopa products.”
Check it at the source: the levodopa FDA label on DailyMed (effective July 20, 2026, Merz Pharmaceuticals, LLC); the tolcapone FDA label on DailyMed (effective October 2, 2020, Bausch Health US LLC).
What does the levodopa label say about tolcapone?
Levodopa's label (effective July 20, 2026) does not name tolcapone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Inbrija), Merz Pharmaceuticals, LLC, effective July 20, 2026 (SPL set 077c0f39-a3a2-4b2b-a184-09131889dcfb), via openFDA; the full label on DailyMed
What does the tolcapone label say about levodopa?
Tolcapone label, drug interactionsIn clinical trials, patients receiving TASMAR/levodopa preparations reported a similar adverse event profile independent of whether or not they were also concomitantly administered selegiline (a selective MAO-B inhibitor).
Tolcapone label, warningsFalling Asleep During Activities of Daily Living and Somnolence Tolcapone (TASMAR) increases plasma levels of levodopa in patients taking concomitant carbidopa levodopa products (see DOSAGE AND ADMINISTRATION ).
Source: FDA drug label (Tasmar), Bausch Health US LLC, effective October 2, 2020 (SPL set a0e47a9d-78e7-4523-983a-aa259f221736), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Levodopa | Tolcapone | |
|---|---|---|
| Labeled for | Parkinson's disease | Parkinson's disease |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once