What the FDA labels say about taking them together
Levodopa and sapropterin
Sapropterin's FDA label of August 26, 2024 names levodopa in its drug interactions section; the levodopa label PlainMeds reads does not name sapropterin. The sapropterin label: “Clinically Relevant Drug Interactions Levodopa Clinical Impact Sapropterin dihydrochloride may increase the availability of tyrosine, a precursor of levodopa. …”
Check it at the source: the levodopa FDA label on DailyMed (effective July 20, 2026, Merz Pharmaceuticals, LLC); the sapropterin FDA label on DailyMed (effective August 26, 2024, BioMarin Pharmaceutical Inc.).
What does the levodopa label say about sapropterin?
Levodopa's label (effective July 20, 2026) does not name sapropterin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Inbrija), Merz Pharmaceuticals, LLC, effective July 20, 2026 (SPL set 077c0f39-a3a2-4b2b-a184-09131889dcfb), via openFDA; the full label on DailyMed
What does the sapropterin label say about levodopa?
Sapropterin label, drug interactionsClinically Relevant Drug Interactions Levodopa Clinical Impact Sapropterin dihydrochloride may increase the availability of tyrosine, a precursor of levodopa. Neurologic events were reported postmarketing in patients receiving sapropterin and levodopa concomitantly for a non-PKU indication [see Warnings and Precautions ( 5.5 )]. Intervention Monitor patients for a change in neurologic status.
Sapropterin label, warnings and precautionsResponse to KUVAN treatment cannot be pre-determined by laboratory (e.g., molecular) testing and can only be determined by a therapeutic trial of KUVAN. ( 5.5 , 2.1 ) Interaction with Levodopa:
Source: FDA drug label (Kuvan), BioMarin Pharmaceutical Inc., effective August 26, 2024 (SPL set af38711e-8873-4790-a92d-4d583e23fb89), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Levodopa | Sapropterin | |
|---|---|---|
| Labeled for | Parkinson's disease | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once