What the FDA labels say about taking them together
Levodopa and pyridoxine
Pyridoxine's FDA label of October 15, 2024 names levodopa in its drug interactions section; the levodopa label PlainMeds reads does not name pyridoxine.
Check it at the source: the levodopa FDA label on DailyMed (effective July 20, 2026, Merz Pharmaceuticals, LLC); the pyridoxine FDA label on DailyMed (effective October 15, 2024, Fresenius Kabi USA, LLC).
What does the levodopa label say about pyridoxine?
Levodopa's label (effective July 20, 2026) does not name pyridoxine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Inbrija), Merz Pharmaceuticals, LLC, effective July 20, 2026 (SPL set 077c0f39-a3a2-4b2b-a184-09131889dcfb), via openFDA; the full label on DailyMed
What does the pyridoxine label say about levodopa?
Pyridoxine label, drug interactionsDrug Interactions Pyridoxine supplements should not be given to patients receiving levodopa, because the action of the latter drug is antagonized by pyridoxine.
Source: FDA drug label (Pyridoxine Hydrochloride), Fresenius Kabi USA, LLC, effective October 15, 2024 (SPL set a56d11c0-b033-4201-85ff-fc710506481a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Levodopa | Pyridoxine | |
|---|---|---|
| Labeled for | Parkinson's disease | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once