What the FDA labels say about taking them together
Levodopa and opicapone
Opicapone's FDA label of October 15, 2025 names levodopa in its warnings and precautions section; the levodopa label PlainMeds reads does not name opicapone. The opicapone label: “May cause or exacerbate dyskinesia; consider levodopa or dopaminergic medication dose reduction. Hallucinations and Psychosis:”
Check it at the source: the levodopa FDA label on DailyMed (effective July 20, 2026, Merz Pharmaceuticals, LLC); the opicapone FDA label on DailyMed (effective October 15, 2025, Amneal Pharmaceuticals LLC).
What does the levodopa label say about opicapone?
Levodopa's label (effective July 20, 2026) does not name opicapone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Inbrija), Merz Pharmaceuticals, LLC, effective July 20, 2026 (SPL set 077c0f39-a3a2-4b2b-a184-09131889dcfb), via openFDA; the full label on DailyMed
What does the opicapone label say about levodopa?
Opicapone label, warnings and precautionsMay cause or exacerbate dyskinesia; consider levodopa or dopaminergic medication dose reduction. ( 5.4 ) Hallucinations and Psychosis:
Source: FDA drug label (ONGENTYS), Amneal Pharmaceuticals LLC, effective October 15, 2025 (SPL set a511a531-112e-43f8-a43f-5334b0efe979), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Levodopa | Opicapone | |
|---|---|---|
| Labeled for | Parkinson's disease | Parkinson's disease |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $24.67 per capsule 25 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once