What the FDA labels say about taking them together
Levodopa and metoclopramide
Levodopa's FDA label of July 20, 2026 names metoclopramide in its drug interactions section, and metoclopramide's label names levodopa too. The levodopa label: “Antagonists and Isoniazid Dopamine D2 receptor antagonists and isoniazid may reduce the effectiveness of levodopa. Monitor patients for worsening Parkinson's symptoms.”
Check it at the source: the levodopa FDA label on DailyMed (effective July 20, 2026, Merz Pharmaceuticals, LLC); the metoclopramide FDA label on DailyMed (effective May 18, 2026, ANI Pharmaceuticals, Inc.).
What does the levodopa label say about metoclopramide?
Levodopa label, drug interactionsAntagonists and Isoniazid Dopamine D2 receptor antagonists (e.g., phenothiazines, butyrophenones, risperidone, metoclopramide) and isoniazid may reduce the effectiveness of levodopa. Monitor patients for worsening Parkinson's symptoms.
Source: FDA drug label (Inbrija), Merz Pharmaceuticals, LLC, effective July 20, 2026 (SPL set 077c0f39-a3a2-4b2b-a184-09131889dcfb), via openFDA; the full label on DailyMed
What does the metoclopramide label say about levodopa?
Metoclopramide label, drug interactionsExamples; apomorphine, bromocriptine, cabergoline, levodopa, pramipexole, ropinirole, and rotigotine
Source: FDA drug label (Metoclopramide), NDA017854 (Ani Pharms), as published by ANI Pharmaceuticals, Inc., effective May 18, 2026 (SPL set 797aad80-0597-42f8-99d5-39de180c3b5a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Levodopa | Metoclopramide | |
|---|---|---|
| Labeled for | Parkinson's disease | Acid reflux and ulcers, Nausea and vomiting |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.0439 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once