What the FDA labels say about taking them together
Letermovir and simvastatin
Letermovir's FDA label of January 14, 2026 names simvastatin in its contraindications section; the simvastatin label PlainMeds reads does not name letermovir. The letermovir label: “Co-administration of PREVYMIS and pitavastatin or simvastatin is not recommended. When PREVYMIS is co-administered with cyclosporine, use of either pitavastatin or simvastatin is contraindicated due to significantly …”
Check it at the source: the letermovir FDA label on DailyMed (effective January 14, 2026, Merck Sharp & Dohme LLC); the simvastatin FDA label on DailyMed (effective March 28, 2025, Organon LLC).
What does the letermovir label say about simvastatin?
Letermovir label, contraindicationsPREVYMIS is contraindicated with pitavastatin and simvastatin when co-administered with cyclosporine.
Letermovir label, drug interactionsConcomitant Drug Class and/or Clearance Pathway/Drug Name: pitavastatin, simvastatin; Effect on Concentration ↓ =decrease, ↑ =increase: ↑ HMG-CoA reductase inhibitors; Clinical Comments: Co-administration of PREVYMIS and pitavastatin or simvastatin is not recommended. When PREVYMIS is co-administered with cyclosporine, use of either pitavastatin or simvastatin is contraindicated due to significantly increased pitavastatin or simvastatin concentrations and risk of myopathy or rhabdomyolysis [see ].
Source: FDA drug label (PREVYMIS), Merck Sharp & Dohme LLC, effective January 14, 2026 (SPL set 1b49df80-be4f-47e0-a0b7-123f3e69395b), via openFDA; the full label on DailyMed
What does the simvastatin label say about letermovir?
Simvastatin's label (effective March 28, 2025) does not name letermovir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ZOCOR), Organon LLC, effective March 28, 2025 (SPL set 8f55d5de-5a4f-4a39-8c84-c53976dd6af9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Letermovir | Simvastatin | |
|---|---|---|
| Labeled for | n/a | Heart attack and coronary artery disease, High cholesterol, High triglycerides |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.0321 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once