What the FDA labels say about taking them together
Letermovir and rosuvastatin
Letermovir's FDA label of January 14, 2026 names rosuvastatin in its drug interactions section; the rosuvastatin labels PlainMeds reads (2) do not name letermovir. The letermovir label: “When PREVYMIS is co-administered with these statins, a statin dosage reduction may be necessary. Closely monitor patients for myopathy and rhabdomyolysis. …”
Check it at the source: the letermovir FDA label on DailyMed (effective January 14, 2026, Merck Sharp & Dohme LLC); the rosuvastatin FDA label on DailyMed (effective September 4, 2026, ScieGen Pharmaceuticals, Inc.).
What does the letermovir label say about rosuvastatin?
Letermovir label, drug interactionsConcomitant Drug Class and/or Clearance Pathway/Drug Name: fluvastatin, lovastatin, pravastatin, rosuvastatin; Effect on Concentration ↓ =decrease, ↑ =increase: ↑ HMG-CoA reductase inhibitors; Clinical Comments: When PREVYMIS is co-administered with these statins, a statin dosage reduction may be necessary. Closely monitor patients for myopathy and rhabdomyolysis. When PREVYMIS is co-administered with cyclosporine, use of lovastatin is not recommended. When PREVYMIS is co-administered with cyclosporine, refer to the statin prescribing information for specific statin dosing recommendations.
Source: FDA drug label (PREVYMIS), Merck Sharp & Dohme LLC, effective January 14, 2026 (SPL set 1b49df80-be4f-47e0-a0b7-123f3e69395b), via openFDA; the full label on DailyMed
What does the rosuvastatin label say about letermovir?
Rosuvastatin's label (effective September 4, 2026) and its 1 other brand-application label do not name letermovir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Rosuvastatin), ScieGen Pharmaceuticals, Inc., effective September 4, 2026 (SPL set ee4933c5-0d97-494d-ac0f-2083e0100836), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Letermovir | Rosuvastatin | |
|---|---|---|
| Labeled for | n/a | Heart attack and coronary artery disease, High cholesterol, High triglycerides, Stroke prevention |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.0692 per tablet 40 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once