What the FDA labels say about taking them together
Letermovir and pitavastatin
Letermovir's FDA label of January 14, 2026 names pitavastatin in its contraindications section; the pitavastatin labels PlainMeds reads (2) do not name letermovir. The letermovir label: “Co-administration of PREVYMIS and pitavastatin or simvastatin is not recommended. When PREVYMIS is co-administered with cyclosporine, use of either pitavastatin or simvastatin is contraindicated due to significantly …”
Check it at the source: the letermovir FDA label on DailyMed (effective January 14, 2026, Merck Sharp & Dohme LLC); the pitavastatin FDA label on DailyMed (effective March 31, 2026, Kowa Pharmaceuticals America, Inc.).
What does the letermovir label say about pitavastatin?
Letermovir label, contraindicationsPREVYMIS is contraindicated with pitavastatin and simvastatin when co-administered with cyclosporine.
Letermovir label, drug interactionsConcomitant Drug Class and/or Clearance Pathway/Drug Name: pitavastatin, simvastatin; Effect on Concentration ↓ =decrease, ↑ =increase: ↑ HMG-CoA reductase inhibitors; Clinical Comments: Co-administration of PREVYMIS and pitavastatin or simvastatin is not recommended. When PREVYMIS is co-administered with cyclosporine, use of either pitavastatin or simvastatin is contraindicated due to significantly increased pitavastatin or simvastatin concentrations and risk of myopathy or rhabdomyolysis [see ].
Source: FDA drug label (PREVYMIS), Merck Sharp & Dohme LLC, effective January 14, 2026 (SPL set 1b49df80-be4f-47e0-a0b7-123f3e69395b), via openFDA; the full label on DailyMed
What does the pitavastatin label say about letermovir?
Pitavastatin's label (effective March 31, 2026) and its 1 other brand-application label do not name letermovir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Livalo), Kowa Pharmaceuticals America, Inc., effective March 31, 2026 (SPL set 44dcbf97-99ec-427c-ba50-207e0069d6d2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Letermovir | Pitavastatin | |
|---|---|---|
| Labeled for | n/a | High cholesterol |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.954 per tablet 2 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once