What the FDA labels say about taking them together
Letermovir and omeprazole
Letermovir's FDA label of January 14, 2026 names omeprazole in its drug interactions section; the omeprazole labels PlainMeds reads (2) do not name letermovir. The letermovir label: “Clinical monitoring and dose adjustment may be needed.”
Check it at the source: the letermovir FDA label on DailyMed (effective January 14, 2026, Merck Sharp & Dohme LLC); the omeprazole FDA label on DailyMed (effective April 22, 2024, Apotex Corp).
What does the letermovir label say about omeprazole?
Letermovir label, drug interactionsConcomitant Drug Class and/or Clearance Pathway/Drug Name: omeprazole; Effect on Concentration ↓ =decrease, ↑ =increase: ↓ omeprazole; Clinical Comments: Clinical monitoring and dose adjustment may be needed.
Source: FDA drug label (PREVYMIS), Merck Sharp & Dohme LLC, effective January 14, 2026 (SPL set 1b49df80-be4f-47e0-a0b7-123f3e69395b), via openFDA; the full label on DailyMed
What does the omeprazole label say about letermovir?
Omeprazole's label (effective April 22, 2024) and its 1 other brand-application label do not name letermovir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Omeprazole), Apotex Corp, effective April 22, 2024 (SPL set b83329ac-a65e-b3af-a3fb-c5a6c740e5e7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Letermovir | Omeprazole | |
|---|---|---|
| Labeled for | n/a | Acid reflux and ulcers |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.0295 per capsule 20 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once