What the FDA labels say about taking them together
Lenacapavir and vardenafil
Lenacapavir's FDA label of August 27, 2026 names vardenafil in its drug interactions section; the vardenafil label PlainMeds reads does not name lenacapavir. The lenacapavir label: “Use of PDE-5 inhibitors for pulmonary arterial hypertension (PAH): Concomitant administration of SUNLENCA with tadalafil for the treatment of PAH is not recommended. …”
Check it at the source: the lenacapavir FDA label on DailyMed (effective August 27, 2026, Gilead Sciences, Inc.); the vardenafil FDA label on DailyMed (effective January 5, 2026, Zydus Pharmaceuticals USA Inc.).
What does the lenacapavir label say about vardenafil?
Lenacapavir label, drug interactionsConcomitant Drug Class/Drug Name: Phosphodiesterase-5 (PDE-5) Inhibitors: sildenafil tadalafil vardenafil; Effect on Concentration ↑ = Increase, ↓ = Decrease.: ↑ PDE-5 inhibitors; Clinical Comment: Use of PDE-5 inhibitors for pulmonary arterial hypertension (PAH): Concomitant administration of SUNLENCA with tadalafil for the treatment of PAH is not recommended. Use of PDE-5 inhibitors for erectile dysfunction (ED): Refer to the prescribing information of PDE-5 inhibitors for dose recommendations.
Source: FDA drug label (Sunlenca), Gilead Sciences, Inc., effective August 27, 2026 (SPL set e5652804-29c4-40d7-aeb2-0142ed2a7b5b), via openFDA; the full label on DailyMed
What does the vardenafil label say about lenacapavir?
Vardenafil's label (effective January 5, 2026) does not name lenacapavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (VARDENAFIL), Zydus Pharmaceuticals USA Inc., effective January 5, 2026 (SPL set 5876e062-e604-42a7-99c3-5da30b8dac06), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lenacapavir | Vardenafil | |
|---|---|---|
| Labeled for | HIV | Erectile dysfunction |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $2.79 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once