What the FDA labels say about taking them together
Lenacapavir and tramadol
Lenacapavir's FDA label of August 27, 2026 names tramadol in its drug interactions section; the tramadol labels PlainMeds reads (3) do not name lenacapavir. The lenacapavir label: “A decrease in dose may be needed for tramadol with concomitant use.”
Check it at the source: the lenacapavir FDA label on DailyMed (effective August 27, 2026, Gilead Sciences, Inc.); the tramadol FDA label on DailyMed (effective March 5, 2026, Lupin Pharmaceuticals, Inc.).
What does the lenacapavir label say about tramadol?
Lenacapavir label, drug interactionsConcomitant Drug Class/Drug Name: tramadol; Effect on Concentration ↑ = Increase, ↓ = Decrease.: ↑ tramadol; Clinical Comment: A decrease in dose may be needed for tramadol with concomitant use.
Source: FDA drug label (Sunlenca), Gilead Sciences, Inc., effective August 27, 2026 (SPL set e5652804-29c4-40d7-aeb2-0142ed2a7b5b), via openFDA; the full label on DailyMed
What does the tramadol label say about lenacapavir?
Tramadol's label (effective March 5, 2026) and its 2 other brand-application labels do not name lenacapavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (TRAMADOL HYDROCHLORIDE), Lupin Pharmaceuticals, Inc., effective March 5, 2026 (SPL set 46bb9ae6-3ee8-463c-badb-c7a45a89b84b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lenacapavir | Tramadol | |
|---|---|---|
| Labeled for | HIV | Pain |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.0248 per tablet 50 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once