What the FDA labels say about taking them together
Lenacapavir and rivaroxaban
Lenacapavir's FDA label of August 27, 2026 names rivaroxaban in its drug interactions section; the rivaroxaban labels PlainMeds reads (2) do not name lenacapavir.
Check it at the source: the lenacapavir FDA label on DailyMed (effective August 27, 2026, Gilead Sciences, Inc.); the rivaroxaban FDA label on DailyMed (effective September 10, 2026, Janssen Pharmaceuticals, Inc.).
What does the lenacapavir label say about rivaroxaban?
Lenacapavir label, drug interactionsConcomitant Drug Class/Drug Name: Anticoagulants: Direct Oral Anticoagulants (DOACs) rivaroxaban dabigatran edoxaban; Effect on Concentration ↑ = Increase, ↓ = Decrease.: ↑ DOAC; Clinical Comment: Refer to the DOAC prescribing information for concomitant administration with moderate CYP3A inhibitors and/or P-gp inhibitors.
Source: FDA drug label (Sunlenca), Gilead Sciences, Inc., effective August 27, 2026 (SPL set e5652804-29c4-40d7-aeb2-0142ed2a7b5b), via openFDA; the full label on DailyMed
What does the rivaroxaban label say about lenacapavir?
Rivaroxaban's label (effective September 10, 2026) and its 1 other brand-application label do not name lenacapavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Xarelto), Janssen Pharmaceuticals, Inc., effective September 10, 2026 (SPL set 10db92f9-2300-4a80-836b-673e1ae91610), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lenacapavir | Rivaroxaban | |
|---|---|---|
| Labeled for | HIV | Atrial fibrillation, Heart attack and coronary artery disease, Blood clots (DVT and PE), Stroke prevention |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.650 per tablet 2.5 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once