What the FDA labels say about taking them together
Lenacapavir and midazolam
Lenacapavir's FDA label of August 27, 2026 names midazolam in its drug interactions section; the midazolam labels PlainMeds reads (4) do not name lenacapavir.
Check it at the source: the lenacapavir FDA label on DailyMed (effective August 27, 2026, Gilead Sciences, Inc.); the midazolam FDA label on DailyMed (effective January 1, 2024, Fresenius Kabi USA, LLC).
What does the lenacapavir label say about midazolam?
Lenacapavir label, drug interactionsConcomitant Drug Class/Drug Name: Sedatives/Hypnotics: midazolam (oral) triazolam; Effect on Concentration ↑ = Increase, ↓ = Decrease.: ↑ midazolam (oral) ↑ triazolam; Clinical Comment: Use with caution when midazolam or triazolam is concomitantly administered with SUNLENCA
Source: FDA drug label (Sunlenca), Gilead Sciences, Inc., effective August 27, 2026 (SPL set e5652804-29c4-40d7-aeb2-0142ed2a7b5b), via openFDA; the full label on DailyMed
What does the midazolam label say about lenacapavir?
Midazolam's label (effective January 1, 2024) and its 3 other brand-application labels do not name lenacapavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Midazolam), Fresenius Kabi USA, LLC, effective January 1, 2024 (SPL set 1cc9ba6e-fa1b-405e-9de8-720c567b2a73), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lenacapavir | Midazolam | |
|---|---|---|
| Labeled for | HIV | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.233 per mL 2 mg/2 mL vial |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once