What the FDA labels say about taking them together
Lenacapavir and methylergonovine
Lenacapavir's FDA label of August 27, 2026 names methylergonovine in its drug interactions section; the methylergonovine label PlainMeds reads does not name lenacapavir. The lenacapavir label: “Concomitant administration of SUNLENCA with dihydroergotamine, ergotamine or methylergonovine is not recommended.”
Check it at the source: the lenacapavir FDA label on DailyMed (effective August 27, 2026, Gilead Sciences, Inc.); the methylergonovine FDA label on DailyMed (effective May 1, 2026, Teva Pharmaceuticals USA, Inc.).
What does the lenacapavir label say about methylergonovine?
Lenacapavir label, drug interactionsConcomitant Drug Class/Drug Name: Ergot derivatives: dihydroergotamine ergotamine methylergonovine; Effect on Concentration ↑ = Increase, ↓ = Decrease.: ↑ dihydroergotamine ↑ ergotamine ↑ methylergonovine; Clinical Comment: Concomitant administration of SUNLENCA with dihydroergotamine, ergotamine or methylergonovine is not recommended.
Source: FDA drug label (Sunlenca), Gilead Sciences, Inc., effective August 27, 2026 (SPL set e5652804-29c4-40d7-aeb2-0142ed2a7b5b), via openFDA; the full label on DailyMed
What does the methylergonovine label say about lenacapavir?
Methylergonovine's label (effective May 1, 2026) does not name lenacapavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Methylergonovine Maleate), Teva Pharmaceuticals USA, Inc., effective May 1, 2026 (SPL set d8e4b8ed-3289-4611-8a61-2392a4bf6072), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lenacapavir | Methylergonovine | |
|---|---|---|
| Labeled for | HIV | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $4.50 per tablet 0.2 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once