What the FDA labels say about taking them together
Leflunomide and theophylline
Leflunomide's FDA label of June 4, 2025 names theophylline in its drug interactions section; the theophylline label PlainMeds reads does not name leflunomide. The leflunomide label: “In patients taking ARAVA, exposure of drugs metabolized by CYP1A2 may be reduced.”
Check it at the source: the leflunomide FDA label on DailyMed (effective June 4, 2025, sanofi-aventis U.S. LLC); the theophylline FDA label on DailyMed (effective March 10, 2026, Strides Pharma Science Limited).
What does the leflunomide label say about theophylline?
Leflunomide label, drug interactionsIn patients taking ARAVA, exposure of drugs metabolized by CYP1A2 (e.g., alosetron, duloxetine, theophylline, tizanidine) may be reduced.
Source: FDA drug label (Arava), sanofi-aventis U.S. LLC, effective June 4, 2025 (SPL set 320f63f2-fac3-4aee-aff8-85724e00ef52), via openFDA; the full label on DailyMed
What does the theophylline label say about leflunomide?
Theophylline's label (effective March 10, 2026) does not name leflunomide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Theophylline), Strides Pharma Science Limited, effective March 10, 2026 (SPL set b7a90ccf-9c32-40cc-9008-7e55b3da4dfd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Leflunomide | Theophylline | |
|---|---|---|
| Labeled for | Rheumatoid arthritis | Asthma |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.324 per tablet 10 mg tablet | $0.330 per tablet 300 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once