What the FDA labels say about taking them together
Ledipasvir/sofosbuvir and magnesium hydroxide
Ledipasvir/sofosbuvir's FDA label of December 26, 2024 names magnesium hydroxide in its drug interactions section; the magnesium hydroxide label PlainMeds reads does not name ledipasvir/sofosbuvir.
Check it at the source: the ledipasvir/sofosbuvir FDA label on DailyMed (effective December 26, 2024, Gilead Sciences, Inc); the magnesium hydroxide FDA label on DailyMed (effective August 21, 2026).
What does the ledipasvir/sofosbuvir label say about magnesium hydroxide?
Ledipasvir/sofosbuvir label, drug interactionsConcomitant Drug Class/Drug Name: Antacids (e.g., aluminum and magnesium hydroxide); Effect on Concentration ↓ = decrease, ↑ = increase: ↓ ledipasvir; Clinical Comment: It is recommended to separate antacid and HARVONI administration by 4 hours.
Source: FDA drug label (Harvoni), Gilead Sciences, Inc, effective December 26, 2024 (SPL set f4ec77e4-bae8-4db0-b3d5-bde09c5fa075), via openFDA; the full label on DailyMed
What does the magnesium hydroxide label say about ledipasvir/sofosbuvir?
Magnesium hydroxide's label (effective August 21, 2026) does not name ledipasvir/sofosbuvir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (MiraFAST soft chews), Bayer HealthCare LLC., effective August 21, 2026 (SPL set 2cee67dd-b71f-32b8-e063-6394a90ae864), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ledipasvir/sofosbuvir | Magnesium hydroxide | |
|---|---|---|
| Labeled for | Hepatitis C | Constipation, Acid reflux and ulcers |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $0.0095 per mL Milk of magnesia suspension |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once