What the FDA labels say about taking them together
Lamotrigine and levonorgestrel
Lamotrigine's FDA label of October 10, 2025 names levonorgestrel in its drug interactions section; the levonorgestrel labels PlainMeds reads (4) do not name lamotrigine. The lamotrigine label: “Decreased lamotrigine concentrations approximately 50%.”
Check it at the source: the lamotrigine FDA label on DailyMed (effective October 10, 2025); the levonorgestrel FDA label on DailyMed (effective January 31, 2023, Foundation Consumer Healthcare LLC).
What does the lamotrigine label say about levonorgestrel?
Lamotrigine label, drug interactionsConcomitant Drug: Estrogen-containing oral contraceptive preparations containing 30 mcg ethinylestradiol and 150 mcg levonorgestrel; Effect on Concentration of Lamotrigine or Concomitant Drug: ↓ lamotrigine ↓ levonorgestrel; Clinical Comment: Decreased lamotrigine concentrations approximately 50%. Decrease in levonorgestrel component by 19%.
Source: FDA drug label (Lamictal Xr, NDA022115), GlaxoSmithKline LLC, effective October 10, 2025 (SPL set 3e2c9a35-6a39-41d7-ad84-3c0bb8894b09), via openFDA
Source: FDA drug label (LAMICTAL), GlaxoSmithKline LLC, effective October 10, 2025 (SPL set d7e3572d-56fe-4727-2bb4-013ccca22678), via openFDA; the full label on DailyMed
What does the levonorgestrel label say about lamotrigine?
Levonorgestrel's label (effective January 31, 2023) and its 3 other brand-application labels do not name lamotrigine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Plan B One-Step), Foundation Consumer Healthcare LLC, effective January 31, 2023 (SPL set 6ce6b40e-14ac-47bd-a648-ddf9e452e559), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lamotrigine | Levonorgestrel | |
|---|---|---|
| Labeled for | Seizures and epilepsy, Bipolar disorder | Birth control |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0268 per tablet 25 mg tablet | $6.33 per tablet 1.5 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once