What the FDA labels say about taking them together
Ketorolac and thiothixene
Ketorolac's FDA label (Sprix) of December 5, 2024 names thiothixene in its drug interactions section; the thiothixene label PlainMeds reads does not name ketorolac.
Check it at the source: the ketorolac FDA label on DailyMed (effective August 31, 2023, Fresenius Kabi USA, LLC); the thiothixene FDA label on DailyMed (effective November 16, 2024, Amneal Pharmaceuticals NY LLC).
What does the ketorolac label say about thiothixene?
Sprix label (Zyla Life Sciences US LLC, December 5, 2024), drug interactionsClinical Impact: Hallucinations have been reported when ketorolac was used in patients taking psychoactive drugs (…). Intervention: During concomitant use of SPRIX and psychoactive drugs, monitor patients for hallucinations.
Source: FDA drug label (Sprix, NDA022382), Zyla Life Sciences US LLC, effective December 5, 2024 (SPL set 97005a1c-167e-4676-bae7-e49b38c36f9e), via openFDA
Source: FDA drug label (Ketorolac Tromethamine), Fresenius Kabi USA, LLC, effective August 31, 2023 (SPL set 3d88cbe6-5230-47aa-80af-0c41283d1f00), via openFDA; the full label on DailyMed
What does the thiothixene label say about ketorolac?
Thiothixene's label (effective November 16, 2024) does not name ketorolac in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (thiothixene), Amneal Pharmaceuticals NY LLC, effective November 16, 2024 (SPL set 81c40311-7dc4-4332-8920-a39a8466aea6), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ketorolac | Thiothixene | |
|---|---|---|
| Labeled for | Pain | Schizophrenia |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $1.02 per mL 30 mg/mL vial | $1.72 per capsule 10 mg capsule |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once