What the FDA labels say about taking them together
Ketoconazole and ubrogepant
Ubrogepant's FDA label of June 5, 2025 names ketoconazole in its drug interactions section; the ketoconazole label PlainMeds reads does not name ubrogepant. The ubrogepant label: “CYP3A4 I nhibitors Co-administration of UBRELVY with ketoconazole, a strong CYP3A4 inhibitor, resulted in a significant increase in exposure of ubrogepant.”
Check it at the source: the ketoconazole FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC); the ubrogepant FDA label on DailyMed (effective June 5, 2025, Allergan, Inc.).
What does the ketoconazole label say about ubrogepant?
Ketoconazole's label (effective January 28, 2026) does not name ubrogepant in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ketoconazole), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set cad7c647-34a9-4e4e-83b3-8d78e58f588f), via openFDA; the full label on DailyMed
What does the ubrogepant label say about ketoconazole?
Ubrogepant label, drug interactionsCYP3A4 I nhibitors Co-administration of UBRELVY with ketoconazole, a strong CYP3A4 inhibitor, resulted in a significant increase in exposure of ubrogepant [see Clinical Pharmacology ( 12.3 ) ].
Source: FDA drug label (UBRELVY), NDA211765 (Abbvie), as published by Allergan, Inc., effective June 5, 2025 (SPL set fd9f9458-fd96-4688-be3f-f77b3d1af6ab), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ketoconazole | Ubrogepant | |
|---|---|---|
| Labeled for | Fungal infections | Migraine |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.249 per gram 2% cream | $109.11 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once