What the FDA labels say about taking them together
Ketoconazole and triazolam
Triazolam's FDA label of July 10, 2026 names ketoconazole in its contraindications section; the ketoconazole label PlainMeds reads does not name triazolam. The triazolam label: “Strong CYP 3A Inhibitors Triazolam is contraindicated in patients receiving strong inhibitors of CYP 3A such as ketoconazole, itraconazole, nefazodone, ritonavir, indinavir, nelfinavir, saquinavir, and lopinavir.”
Check it at the source: the ketoconazole FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC); the triazolam FDA label on DailyMed (effective July 10, 2026, Mylan Pharmaceuticals Inc.).
What does the ketoconazole label say about triazolam?
Ketoconazole's label (effective January 28, 2026) does not name triazolam in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ketoconazole), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set cad7c647-34a9-4e4e-83b3-8d78e58f588f), via openFDA; the full label on DailyMed
What does the triazolam label say about ketoconazole?
Triazolam label, contraindicationsConcomitant administration of strong cytochrome P450 (CYP 3A) enzyme inhibitors (e.g., ketoconazole, itraconazole, nefazodone, lopinavir, ritonavir) [see Warnings and Precautions (5.8), Drug Interactions (7.1) ]. Known hypersensitivity to triazolam or other benzodiazepines
Triazolam label, warnings and precautionsStrong CYP 3A Inhibitors Triazolam is contraindicated in patients receiving strong inhibitors of CYP 3A such as ketoconazole, itraconazole, nefazodone, ritonavir, indinavir, nelfinavir, saquinavir, and lopinavir [see Contraindications (4), Drug Interactions (7.1) ].
Source: FDA drug label (Triazolam), NDA017892 (Pfizer), as published by Mylan Pharmaceuticals Inc., effective July 10, 2026 (SPL set 5add318e-11b9-42f8-b052-0d8cebb32fcf), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ketoconazole | Triazolam | |
|---|---|---|
| Labeled for | Fungal infections | Insomnia |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.249 per gram 2% cream | $0.308 per tablet 0.25 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once