What the FDA labels say about taking them together
Ketoconazole and triamcinolone
Triamcinolone's FDA label (Triesence) of June 5, 2026 names ketoconazole in its drug interactions section; the ketoconazole label PlainMeds reads does not name triamcinolone. The triamcinolone label: “CYP 3A4 inhibitors: Ketoconazole has been reported to decrease the metabolism of certain corticosteroids by up to 60% leading to an increased risk of corticosteroid side effects.”
Check it at the source: the ketoconazole FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC); the triamcinolone FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC).
What does the ketoconazole label say about triamcinolone?
Ketoconazole's label (effective January 28, 2026) does not name triamcinolone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ketoconazole), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set cad7c647-34a9-4e4e-83b3-8d78e58f588f), via openFDA; the full label on DailyMed
What does the triamcinolone label say about ketoconazole?
Triesence label (Harrow Eye, LLC, June 5, 2026), drug interactionsCYP 3A4 inhibitors (e.g., ketoconazole, macrolide antibiotics): Ketoconazole has been reported to decrease the metabolism of certain corticosteroids by up to 60% leading to an increased risk of corticosteroid side effects.
Source: FDA drug label (Triesence, NDA022048), Harrow Eye, LLC, effective June 5, 2026 (SPL set 2267978c-72ad-9229-e063-6394a90a09d0), via openFDA
Source: FDA drug label (Zilretta, NDA208845), Pacira Pharmaceuticals, Inc., effective June 3, 2026 (SPL set cd5c4673-21f2-4126-9556-da847b3a228b), via openFDA
Source: FDA drug label (triamcinolone acetonide), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set 92a1ded0-8e1a-4994-9c8a-89e84fc85c94), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ketoconazole | Triamcinolone | |
|---|---|---|
| Labeled for | Fungal infections | Asthma, Eczema (atopic dermatitis), Anemia, Leukemia, lymphoma and myeloma, Allergies, Fever, Pain, Osteoarthritis |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.249 per gram 2% cream | $0.0452 per gram 0.1% cream |
| Shortage now | No current entry | Listed; available |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once