What the FDA labels say about taking them together
Ketoconazole and nintedanib
Nintedanib's FDA label of November 20, 2025 names ketoconazole in its drug interactions section; the ketoconazole label PlainMeds reads does not name nintedanib. The nintedanib label: “Coadministration with oral doses of a P-gp and CYP3A4 inhibitor, ketoconazole, increased exposure to nintedanib by 60%.”
Check it at the source: the ketoconazole FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC); the nintedanib FDA label on DailyMed (effective November 20, 2025, Boehringer Ingelheim Pharmaceuticals, Inc.).
What does the ketoconazole label say about nintedanib?
Ketoconazole's label (effective January 28, 2026) does not name nintedanib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ketoconazole), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set cad7c647-34a9-4e4e-83b3-8d78e58f588f), via openFDA; the full label on DailyMed
What does the nintedanib label say about ketoconazole?
Nintedanib label, drug interactionsCoadministration with oral doses of a P-gp and CYP3A4 inhibitor, ketoconazole, increased exposure to nintedanib by 60%.
Source: FDA drug label (Ofev), Boehringer Ingelheim Pharmaceuticals, Inc., effective November 20, 2025 (SPL set da1c9f37-779e-4682-816f-93d0faa4cfc9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ketoconazole | Nintedanib | |
|---|---|---|
| Labeled for | Fungal infections | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.249 per gram 2% cream | $13.46 per capsule 150 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once