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What the FDA labels say about taking them together

Ketoconazole and nevirapine

Nevirapine's FDA label of July 15, 2026 names ketoconazole in its drug interactions section; the ketoconazole label PlainMeds reads does not name nevirapine. The nevirapine label: “Nevirapine and ketoconazole should not be administered concomitantly because decreases in ketoconazole plasma concentrations may reduce the efficacy of the drug.”

Check it at the source: the ketoconazole FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC); the nevirapine FDA label on DailyMed (effective July 15, 2026, Mylan Pharmaceuticals Inc.).

What does the ketoconazole label say about nevirapine?

Ketoconazole's label (effective January 28, 2026) does not name nevirapine in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (ketoconazole), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set cad7c647-34a9-4e4e-83b3-8d78e58f588f), via openFDA; the full label on DailyMed

What does the nevirapine label say about ketoconazole?

Nevirapine label, drug interactions

Drug Name: Ketoconazole; Effect on Concentration of Nevirapine or Concomitant Drug: ↓ Ketoconazole; Clinical Comment: Nevirapine and ketoconazole should not be administered concomitantly because decreases in ketoconazole plasma concentrations may reduce the efficacy of the drug.

Source: FDA drug label (Nevirapine), Mylan Pharmaceuticals Inc., effective July 15, 2026 (SPL set c6e93829-7024-48f6-8023-da6ff27dfc0a), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

30Ketoconazole generic labelers
6Nevirapine generic labelers
KetoconazoleNevirapine
Labeled forFungal infectionsHIV
Boxed warningNoYes
Pharmacy cost (NADAC)$0.249 per gram 2% cream$0.147 per tablet 200 mg tablet
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?