What the FDA labels say about taking them together
Ketamine and memantine
Memantine's FDA label of November 1, 2018 names ketamine in its drug interactions section; the ketamine label PlainMeds reads does not name memantine.
Check it at the source: the ketamine FDA label on DailyMed (effective March 27, 2026, Par Health USA, LLC); the memantine FDA label on DailyMed (effective November 1, 2018, Actavis Pharma, Inc.).
What does the ketamine label say about memantine?
Ketamine's label (effective March 27, 2026) does not name memantine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Ketalar), Par Health USA, LLC, effective March 27, 2026 (SPL set 14e8f864-8b8a-4e7e-8439-e510d3107063), via openFDA; the full label on DailyMed
What does the memantine label say about ketamine?
Memantine label, drug interactionsUse with Other N-methyl-D-aspartate (NMDA) Antagonists The combined use of memantine hydrochloride with other NMDA antagonists (amantadine, ketamine, and dextromethorphan) has not been systematically evaluated and such use should be approached with caution.
Source: FDA drug label (memantine hydrochloride), NDA021487 (Abbvie), as published by Actavis Pharma, Inc., effective November 1, 2018 (SPL set 72973b46-f307-4a9e-8fb1-ad2cbccfd736), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ketamine | Memantine | |
|---|---|---|
| Labeled for | n/a | Alzheimer's disease |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.556 per mL 500 mg/10 mL vial | $0.063 per tablet 10 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once