What the FDA labels say about taking them together
Ivacaftor/lumacaftor and sirolimus
Ivacaftor/lumacaftor's FDA label of March 24, 2026 names sirolimus in its drug interactions section; the sirolimus labels PlainMeds reads (4) do not name ivacaftor/lumacaftor. The ivacaftor/lumacaftor label: “Immunosuppressants: cyclosporine, everolimus, sirolimus, and tacrolimus (avoid the use of ORKAMBI).”
Check it at the source: the ivacaftor/lumacaftor FDA label on DailyMed (effective March 24, 2026, Vertex Pharmaceuticals Incorporated); the sirolimus FDA label on DailyMed (effective January 28, 2026, Glenmark Pharmaceuticals Inc., USA).
What does the ivacaftor/lumacaftor label say about sirolimus?
Ivacaftor/lumacaftor label, drug interactionsImmunosuppressants: cyclosporine, everolimus, sirolimus, and tacrolimus (avoid the use of ORKAMBI).
Source: FDA drug label (ORKAMBI), Vertex Pharmaceuticals Incorporated, effective March 24, 2026 (SPL set 3fc1c40e-cfac-47a1-9e1a-61ead3570600), via openFDA; the full label on DailyMed
What does the sirolimus label say about ivacaftor/lumacaftor?
Sirolimus's label (effective January 28, 2026) and its 3 other brand-application labels do not name ivacaftor/lumacaftor in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (sirolimus), Glenmark Pharmaceuticals Inc., USA, effective January 28, 2026 (SPL set 57fb4d90-3ccb-4a69-af1e-53be83f7a504), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ivacaftor/lumacaftor | Sirolimus | |
|---|---|---|
| Labeled for | n/a | Organ transplant rejection |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.723 per tablet 1 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once