What the FDA labels say about taking them together
Ivacaftor/lumacaftor and methylprednisolone
Ivacaftor/lumacaftor's FDA label of March 24, 2026 names methylprednisolone in its drug interactions section; the methylprednisolone labels PlainMeds reads (3) do not name ivacaftor/lumacaftor. The ivacaftor/lumacaftor label: “Concomitant use of ORKAMBI may reduce the exposure and effectiveness of prednisone and methylprednisolone.”
Check it at the source: the ivacaftor/lumacaftor FDA label on DailyMed (effective March 24, 2026, Vertex Pharmaceuticals Incorporated); the methylprednisolone FDA label on DailyMed (effective June 22, 2026, Mylan Pharmaceuticals Inc.).
What does the ivacaftor/lumacaftor label say about methylprednisolone?
Ivacaftor/lumacaftor label, drug interactionsConcomitant use of ORKAMBI may reduce the exposure and effectiveness of prednisone and methylprednisolone.
Source: FDA drug label (ORKAMBI), Vertex Pharmaceuticals Incorporated, effective March 24, 2026 (SPL set 3fc1c40e-cfac-47a1-9e1a-61ead3570600), via openFDA; the full label on DailyMed
What does the methylprednisolone label say about ivacaftor/lumacaftor?
Methylprednisolone's label (effective June 22, 2026) and its 2 other brand-application labels do not name ivacaftor/lumacaftor in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Methylprednisolone), NDA011153 (Pfizer), as published by Mylan Pharmaceuticals Inc., effective June 22, 2026 (SPL set 22dd75d6-f89a-44f7-8ca6-b64c4e9806dd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ivacaftor/lumacaftor | Methylprednisolone | |
|---|---|---|
| Labeled for | n/a | Osteoarthritis, Allergies, Herpes and shingles, Leukemia, lymphoma and myeloma, Crohn's disease and ulcerative colitis, Multiple sclerosis, Asthma, Eczema (atopic dermatitis), Anemia |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.121 per tablet 4 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once