What the FDA labels say about taking them together
Ivacaftor/lumacaftor and lansoprazole
Ivacaftor/lumacaftor's FDA label of March 24, 2026 names lansoprazole in its drug interactions section; the lansoprazole labels PlainMeds reads (2) do not name ivacaftor/lumacaftor. The ivacaftor/lumacaftor label: “Proton Pump Inhibitors, H 2 Blockers, Antacids ORKAMBI may reduce the exposure and effectiveness of proton pump inhibitors such as omeprazole, esomeprazole, and lansoprazole, and may alter the exposure of ranitidine.”
Check it at the source: the ivacaftor/lumacaftor FDA label on DailyMed (effective March 24, 2026, Vertex Pharmaceuticals Incorporated); the lansoprazole FDA label on DailyMed (effective June 24, 2025, L. Perrigo Company).
What does the ivacaftor/lumacaftor label say about lansoprazole?
Ivacaftor/lumacaftor label, drug interactionsProton Pump Inhibitors, H 2 Blockers, Antacids ORKAMBI may reduce the exposure and effectiveness of proton pump inhibitors such as omeprazole, esomeprazole, and lansoprazole, and may alter the exposure of ranitidine.
Source: FDA drug label (ORKAMBI), Vertex Pharmaceuticals Incorporated, effective March 24, 2026 (SPL set 3fc1c40e-cfac-47a1-9e1a-61ead3570600), via openFDA; the full label on DailyMed
What does the lansoprazole label say about ivacaftor/lumacaftor?
Lansoprazole's label (effective June 24, 2025) and its 1 other brand-application label do not name ivacaftor/lumacaftor in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Prevacid 24 HR), L. Perrigo Company, effective June 24, 2025 (SPL set 205c9c1e-b422-4e86-a4b0-714b608adc19), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ivacaftor/lumacaftor | Lansoprazole | |
|---|---|---|
| Labeled for | n/a | Acid reflux and ulcers |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.106 per capsule 30 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once