What the FDA labels say about taking them together
Ivacaftor and tacrolimus
Ivacaftor's FDA label of March 23, 2026 names tacrolimus in its drug interactions section; the tacrolimus labels PlainMeds reads (4) do not name ivacaftor. The ivacaftor label: “Therefore, caution and appropriate monitoring are recommended when co-administering KALYDECO with sensitive CYP3A and/or P-gp substrates, such as digoxin, cyclosporine, and tacrolimus [ see Clinical Pharmacology ].”
Check it at the source: the ivacaftor FDA label on DailyMed (effective March 23, 2026, Vertex Pharmaceuticals Incorporated); the tacrolimus FDA label on DailyMed (effective July 17, 2026, Stellon Biotech Inc.).
What does the ivacaftor label say about tacrolimus?
Ivacaftor label, drug interactionsTherefore, caution and appropriate monitoring are recommended when co-administering KALYDECO with sensitive CYP3A and/or P-gp substrates, such as digoxin, cyclosporine, and tacrolimus [ see Clinical Pharmacology (12.3) ].
Source: FDA drug label (Kalydeco), Vertex Pharmaceuticals Incorporated, effective March 23, 2026 (SPL set 0ab0c9f8-3eee-4e0f-9f3f-c1e16aaffe25), via openFDA; the full label on DailyMed
What does the tacrolimus label say about ivacaftor?
Tacrolimus's label (effective July 17, 2026) and its 3 other brand-application labels do not name ivacaftor in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tacrolimus), Stellon Biotech Inc., effective July 17, 2026 (SPL set 6b89e8a4-9f11-42e3-8e79-fe617e7c461f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ivacaftor | Tacrolimus | |
|---|---|---|
| Labeled for | n/a | Organ transplant rejection, Eczema (atopic dermatitis) |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.970 per gram 0.1% ointment |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once