What the FDA labels say about taking them together
Ivacaftor and midazolam
Ivacaftor's FDA label of March 23, 2026 names midazolam in its drug interactions section; the midazolam labels PlainMeds reads (4) do not name ivacaftor. The ivacaftor label: “Co-administration with oral midazolam, a sensitive CYP3A substrate, increased midazolam exposure 1.5-fold, consistent with weak inhibition of CYP3A by ivacaftor.”
Check it at the source: the ivacaftor FDA label on DailyMed (effective March 23, 2026, Vertex Pharmaceuticals Incorporated); the midazolam FDA label on DailyMed (effective January 1, 2024, Fresenius Kabi USA, LLC).
What does the ivacaftor label say about midazolam?
Ivacaftor label, drug interactionsCo-administration with oral midazolam, a sensitive CYP3A substrate, increased midazolam exposure 1.5-fold, consistent with weak inhibition of CYP3A by ivacaftor.
Source: FDA drug label (Kalydeco), Vertex Pharmaceuticals Incorporated, effective March 23, 2026 (SPL set 0ab0c9f8-3eee-4e0f-9f3f-c1e16aaffe25), via openFDA; the full label on DailyMed
What does the midazolam label say about ivacaftor?
Midazolam's label (effective January 1, 2024) and its 3 other brand-application labels do not name ivacaftor in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Midazolam), Fresenius Kabi USA, LLC, effective January 1, 2024 (SPL set 1cc9ba6e-fa1b-405e-9de8-720c567b2a73), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ivacaftor | Midazolam | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.233 per mL 2 mg/2 mL vial |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once