What the FDA labels say about taking them together
Itraconazole and vonoprazan
Vonoprazan's FDA label of July 16, 2026 names itraconazole in its drug interactions section; the itraconazole labels PlainMeds reads (2) do not name vonoprazan. The vonoprazan label: “Other Drugs Clinical Effect Vonoprazan reduces intragastric acidity, which may decrease the absorption of drugs reducing their effectiveness.”
Check it at the source: the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.); the vonoprazan FDA label on DailyMed (effective July 16, 2026, Phathom Pharmaceuticals Inc.).
What does the itraconazole label say about vonoprazan?
Itraconazole's label (effective July 13, 2026) and its 1 other brand-application label do not name vonoprazan in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
What does the vonoprazan label say about itraconazole?
Vonoprazan label, drug interactionsOther Drugs (e.g., iron salts, erlotinib, dasatinib, nilotinib, mycophenolate mofetil, ketoconazole/itraconazole) Clinical Effect Vonoprazan reduces intragastric acidity [see Clinical Pharmacology (12.2) ], which may decrease the absorption of drugs reducing their effectiveness.
Source: FDA drug label (VOQUEZNA), Phathom Pharmaceuticals Inc., effective July 16, 2026 (SPL set 0cc52ac5-77ec-4d66-a770-762a1a960914), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Itraconazole | Vonoprazan | |
|---|---|---|
| Labeled for | Fungal infections | Acid reflux and ulcers |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.910 per capsule 100 mg capsule | $22.41 per tablet 20 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once