What the FDA labels say about taking them together
Itraconazole and vincristine
Vincristine's FDA label of February 17, 2026 names itraconazole in its drug interactions section; the itraconazole labels PlainMeds reads (2) do not name vincristine. The vincristine label: “Concurrent administration of vincristine sulfate with itraconazole or fluconazole has been reported to cause an earlier onset and/or an increased severity of neuromuscular side effects (see ADVERSE REACTIONS ).”
Check it at the source: the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.); the vincristine FDA label on DailyMed (effective February 17, 2026, Hospira, Inc.).
What does the itraconazole label say about vincristine?
Itraconazole's label (effective July 13, 2026) and its 1 other brand-application label do not name vincristine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
What does the vincristine label say about itraconazole?
Vincristine label, drug interactionsConcurrent administration of vincristine sulfate with itraconazole or fluconazole (known inhibitors of the CYP3A metabolic pathway) has been reported to cause an earlier onset and/or an increased severity of neuromuscular side effects (see ADVERSE REACTIONS ).
Source: FDA drug label (VinCRIStine Sulfate), Hospira, Inc., effective February 17, 2026 (SPL set b22e4c8e-dbe1-4d4b-a026-e1812974071c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Itraconazole | Vincristine | |
|---|---|---|
| Labeled for | Fungal infections | Leukemia, lymphoma and myeloma |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.910 per capsule 100 mg capsule | n/a |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once